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William Klein: Faculty Experts

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William Klein

Northwestern University Feinberg School of Medicine, Weinberg College of Arts and Sciences

Professor of Neurobiology
Weinberg College of Arts and Sciences
Professor of Neurology
Feinberg School of Medicine


Areas of Focus

  • Alzheimer’s disease mechanisms
  • Alzheimer's drug discovery and diagnostics


  • The impact of neurotoxic amyloid beta oligomers (AβOs) is under investigation as a basis for the cause, diagnosis and treatment of AD.
  • Our team discovered AβOs' ability to damage brain cells and disrupt memory mechanisms. The impact of AβOs is now regarded as a central toxic event in Alzheimer's disease.
  • Many projects are in progress that target AβOs for clinical purposes. These include work in high-throughput screening to discover neuroprotective compounds; AD immunotherapy; the search for causes of AβO buildup; the development of MRI and PET brain imaging of AβOs for diagnostics; and the invention of ultrasensitive assays for AD blood tests.