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Renee C. B. Manworren: Faculty Experts

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Renee C. B. Manworren

Northwestern University Feinberg School of Medicine

Associate Professor of Pediatrics, Northwestern University’s Feinberg School of Medicine
Posy & Fred Love Chair in Nursing Research; Director of Nursing Research and Professional Practice
Pediatric Pain Management Specialist
Ann & Robert H. Lurie Children’s Hospital of Chicago


Areas of Focus

  • Children's pain, especially predictable pain and pain in children with communication limitations
  • Impact of opioid epidemic on children's pain treatment
  • Opioid prescribing to relieve pediatric pain
  • Opioid-induced euphoria and prevention of opioid misuse
  • Acute, post-operative and procedural pediatric pain management
  • Individual differences in pain sensitivity and analgesic metabolism
  • Multimodal analgesia


Using Clinical, implementation, translational and educational science (CITES) to:

  • Culturally transform  sensitivities to children's pain so that we can better prevent, assess, treat and understand children's pain
  • Characterize challenges in controlling pain, including genetic and epigenetic risks
  • Develop tools for children unable to self-report pain
  • Link biomarkers for pain sensitivity, analgesic metabolism and opioid-induced euphoria
  • Discover predictors of opioid need and adverse pain treatment outcomes, including opioid misuse
  • Innovate opioid use monitoring, securement and disposal
  • Explain transition from acute to chronic pain
  • Make Chicago Childkind; then America; then the World


Recognized as one of the 2500 most influential nurses in the world, Manworren has described genetic associations with analgesic ineffectiveness and adverse effects. She has conducted investigator-led trials of pharmacologic and biobehavioral interventions for children’s pain, including self-management techniques (self-hypnosis ), topical anesthetics and multimodal treatment strategies. As an international expert in her field and Mayday Society and Pain Fellow, Manworren is active in developing clinical practice guidelines, including post-operative pain management. Manworren's first tool related to pediatric pain has been translated, used and cited by authors from 42 countries on six continents. Email her for permission to use her copyrighted tools free of charge.