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Dr. Douglas Vaughan

Northwestern University Feinberg School of Medicine

Irving S. Cutter Professor of Medicine
Chair, Department of Medicine

About

Areas of Focus

  • Aging
  • Cardiovascular disease
  • Genetics
  • Experimental therapeutics

Work/Research

  • Endothelial function
  • Vascular biology
  • Senescence and aging
  • Plasminogen activator system in aging and aging-related disease
  • Genetics of aging
  • Novel therapeutics to prevent aging and aging-related morbidity

Career

I am currently the Irving S. Cutter Professor of Medicine and Chairman of the Department of Medicine at Northwestern University Feinberg School of Medicine and Physician in Chief of Northwestern Memorial Hospital. Prior to moving to Northwestern in June 2008, I was Professor of Medicine and Pharmacology, C. Sidney Burwell Professor of Medicine, Chief, Division of Cardiovascular Medicine, and Physician in Chief of the Vanderbilt Heart and Vascular Institute at Vanderbilt University Medical Center, in Nashville, Tennessee. For the last three decades, my laboratory has been involved in basic and preclinical investigations that have helped to define the molecular physiology of PAI-1 and its role in arteriosclerosis, metabolism, senescence and aging. Moreover, we have performed numerous physiological and mechanistic investigations that have identified key regulators of PAI-1 and its role in aging and aging-related disease in mice and in man. Based on this long-term focus and cumulative investigative experience, my research group is now extensively involved in testing the efficacy of small molecule orally-active selective PAI-1 inhibitors in a variety of preclinical models as we prepare for eventual use in man.