Dr. Douglas Vaughan: Faculty Experts
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Dr. Douglas Vaughan
Northwestern University Feinberg School of Medicine
Director, Potocsnak Longevity Institute
Irving S. Cutter Professor of Medicine Emeritus
Areas of Focus
- Aging and longevity
- Cardiovascular disease
- Experimental therapeutics
- PAI-1's role in aging and aging-related disease
- Endothelial function
- Vascular biology
- Senescence and aging
- Plasminogen activator system in aging and aging-related disease
- Genetics of aging
- Novel therapeutics to prevent aging and aging-related morbidity
Dr. Vaughan is currently the Irving S. Cutter Professor of Medicine Emeritus at Northwestern University Feinberg School of Medicine and the director of the Potocsnak Longevity Institute, which brings together scientists and experts across many disciplines to study populations that seem resistant to negative consequences of aging to discover what makes them unique. He also is Physician in Chief of Northwestern Memorial Hospital. Previously, Vaughan was the chair of the Department of Medicine at Feinberg.
For the last three decades, his laboratory has been involved in basic and preclinical investigations that have helped to define the molecular physiology of PAI-1 and its role in arteriosclerosis, metabolism, senescence and aging. Moreover, his lab has performed numerous physiological and mechanistic investigations that have identified key regulators of PAI-1 and its role in aging and aging-related disease in mice and in humans. Based on this long-term focus and cumulative investigative experience, his research group is now extensively involved in testing the efficacy of small molecule orally-active selective PAI-1 inhibitors in a variety of preclinical models as we prepare for eventual use in humans.
Prior to moving to Northwestern in June 2008, he was a professor of medicine and pharmacology, the C. Sidney Burwell Professor of Medicine, the chief of cardiovascular medicine and Physician in Chief of the Vanderbilt Heart and Vascular Institute at Vanderbilt University Medical Center, in Nashville, Tenn.