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Evidence Points to Potential Benefits of Polypill for Heart Health

Latest research on polypills could shape the future of cardiovascular care around the world

CHICAGO --- Taking one pill instead of three could be a powerful ally to prevent cardiovascular disease, according to a new Cochrane systematic review of the latest research on polypills from a team of scientists at the London School of Hygiene & Tropical Medicine, Warwick Medical School and Northwestern Medicine®.

A polypill typically combines an aspirin, statin and at least one blood pressure medication into a single pill. The idea of putting multiple drugs into a single pill is not new; it is done in HIV combination therapy, for example. However, polypills have the potential for widespread use and could potentially help prevent heart attacks and stroke while helping people live longer. Such drug combinations are not yet on the market in the U.S. or the UK but can be bought online.

The review included analysis of 7,047 patients in nine randomized controlled trials from around the world from 2009 to 2013 and is the largest and most comprehensive review of polypill literature to date. The findings were published April 16 in the Cochrane Database of Systematic Reviews.

Scientists found that the combination therapy -- taking one pill instead of three separate pills -- made it easier for people to adhere to a treatment plan. In one large study, polypills were shown to improve adherence by 33 percent compared with those who underwent usual care for cardiovascular disease prevention, the scientists said.

In several of the latest studies, the scientists found that a polypill lowered systolic blood pressure and total cholesterol but the overall effects of a polypill may be similar to usual care. Adverse events were more common in people treated with a polypill but there was no strong evidence of a difference in serious adverse events between those taking a polypill and those on placebo or control.

“We know that half of the people around the world who have had a heart attack or stroke take zero medicines after the incident,” said Mark Huffman, M.D., corresponding author of the review. “A single polypill could not only make it easier for patients to take their medications, but could also provide the maximal benefit from a single pill. However, there is not going to be one magical pill for everybody. I think we can expect different polypills with different doses of medication.”

Huffman is an assistant professor in preventive medicine and medicine-cardiology at Northwestern University Feinberg School of Medicine and a cardiologist at Northwestern Memorial Hospital. He is also the coordinating editor of the Cochrane Heart Group Satellite United States, which is based at the Feinberg School.

"Cardiovascular diseases, including heart attacks and strokes, are the leading cause of death and disability worldwide," said Shah Ebrahim, study co-author and professor of public health at the London School of Hygiene & Tropical Medicine. "In the Britain, they cause about a third of all deaths -- more than 180,000 each year. Lowering blood pressure and cholesterol levels by introduction of a polypill could simplify treatment, improve adherence and thereby save lives and reduce health care costs.”

Huffman said the polypill has the potential to be added to the World Health Organization’s “Model List of Essential Medicines” in the future, maybe as soon as next year.

“The WHO has already named the polypill one of the ‘top five best buys’ for preventing chronic diseases globally, and while more research is needed, the polypill has the potential to avoid millions of premature deaths and related morbidity from cardiovascular disease at low cost,” he said.

Funding for this paper comes from the Feinberg School of Medicine, Warwick Medical School, University of Warwick, UK, Department of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, UK, NIHR Cochrane Programme Grant, UK, the National Institute for Health Research Collaboration for Leadership in Applied, Health Research, Care West Midlands at University Hospitals Birmingham and NHS Foundation Trust, UK.

The paper is titled “Fixed-dose combination therapy for the prevention of cardiovascular disease.” Authors include: de Cates AN, Farr MRB, Wright N, Jarvis MC, Rees K, Ebrahim S, Huffman MD. Cochrane Database of Systematic Reviews 2014, Issue 4. Art. No.: CD009868. DOI: 10.1002/14651858.CD009868.pub2.

About the London School of Hygiene & Tropical Medicine
The London School of Hygiene & Tropical Medicine is a world-leading centre for research and postgraduate education in public and global health, with 3,900 students and more than 1,000 staff working in over 100 countries. The School is one of the highest-rated research institutions in the UK, and was recently cited as the world’s leading research-focused graduate school. Our mission is to improve health and health equity in the UK and worldwide; working in partnership to achieve excellence in public and global health research, education and translation of knowledge into policy and practice.

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